Nitric oxide (NO) has been recognized for decades as an important biological signaling molecule. Its role in vascular function and skin physiology is particularly fascinating. In dermatology, NO plays a crucial part in microcirculation, inflammation, immune signaling, wound healing, and other skin-relevant processes. This makes it a credible target for skincare and wound-care innovation. However, it also presents a formulation challenge: while the biology is real, delivering